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. 2022 Nov 15;10(11):2931. doi: 10.3390/biomedicines10112931

Figure 1.

Figure 1

Model diagrams (A,C) and sensitivity plots (B,D) of the mediation analyses examining whether the association between Black/African American race and Luminal B breast carcinoma is mediated by BMI before (A,B) and after (C,D) controlling for the menopausal status. ACME, average causal mediation effect; ADE, average direct effect; a, regression coefficient between Black/African American race and BMI; b, regression coefficient between BMI and Luminal B cancer when controlled for Black/African American race; c, regression coefficient between Black/African American race and Luminal B cancer; c’, regression coefficient between Black/African American race and Luminal B cancer when controlled for BMI; τ, sensitivity parameter required to nullify ACME. Confidence intervals have been obtained using a non-parametric bootstrap approach (1000 simulations). Light colored arrows arising from the covariate Menopause represent the regression coefficients between Menopause and each outcome variable (i.e., BMI and Luminal B cancer) in each model.