Include	Exclude	Explanation for Exclusion
1. Zhao et al. PUMCH experience and strategy for the management of idiopathic macular hole: a retrospective cohort study. International Ophthalmology 2022; 42: 1133–1145.		Do not use iOCT Three refractory cases of IMH (idiopathic macular holes) underwent iOCT assisted PPV + dub-retinal BSS injection, with successful closure	Another main topic
2. Zakir et al. The outcomes and usefulness of Intraoperative Optical Coherence Tomography in vitreoretinal surgery and its impact on surgical decision making. Romanian Journal of Ophthalmology 2022; 66: 55–60.		Vitreoretinal surgery -16 patients -pilot, prospective case series	Another main topic
3. Nct. Efficiency of Intraoperative Optical Coherence Tomography (iOCT). 2022. Available online: https://clinicaltrialsgov/show/NCT05232539 (accessed on 18 August 2022).		Ongoing study	Ongoing study
4. Muijzer et al. Clinical applications for intraoperative optical coherence tomography: a systematic review. Eye 2022; 36: 379–391.		Systematic review	Systematic review
5. Jiwei et al. Application value assessment of intraoperative optical coherence tomography in vitreoretinal surgery. [Chinese]. Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology 2022; 40: 35–40.		Chinese	Another language
6. Benda and Studeny. Intraoperative Optical Coherence Tomography -Available Technologies and Possibilities of Use. A Review. Ceska a Slovenska Oftalmologie 2022; 2: 1001–1010.			Review
7. Yee et al. iOCT-assisted macular hole surgery: outcomes and utility from the DISCOVER study. British Journal of Ophthalmology 2021; 105: 403–409.	84 eyes
8. Wylegala et al. Intraoperative OCT microscopy in 3D. Expert Review of Medical Devices 2021; 18: 221–224.		Description of IOCT use	Review
9. Tao et al. Feasibility and utility of intraoperative optical coherence tomography during vitreoretinal surgery: A 4-year report in Chinese population. Journal of Innovative Optical Health Sciences 2021; 14.	339 eyes Retrospective
10. Takeuchi et al. Intraoperative and Postoperative Monitoring of Autologous Neurosensory Retinal Flap Transplantation for a Refractory Macular Hole Associated with High Myopia. Retina 2021; 41: 921–930.		5 patients High myopic refractory MH Prospective Autologous neurosensory retinal flap transplantation (ART)	Cohort < 8
11. Nishitsuka et al. Intraoperative Observation of a Macular Holes Using Optical Coherence Tomography. Clinical Optometry 2021; 13: 113–118.	10 eyes Anatomical outcomes
12. Leisser et al. Effect of Iatrogenic Traction during Macular Peeling Surgery on Postoperative Microperimetry. Ophthalmic Research 2021; 64:273–279.		25 cases Transient retinal thickening due to tractional forces during peeling documented with iOCT	Another main topic
13. Juergens et al. Intraoperative OCT-Real-World User Evaluation in Routine Surgery. Klinische Monatsblatter fur Augenheilkunde 2021; 238: 693–699.		Not limited to MH	Another main topic
14. Huang et al. Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes. Ophthalmic Surgery, Lasers & Imaging Retina 2021; 52: 544–550.		Clinical and EZ-integrity outcomes in VMT	Another main topic
15. Cai et al. Pediatric Vitreoretinal Surgery and Integrated Intraoperative Optical Coherence Tomography. Developments in Ophthalmology 2021; 61: 15–25.		Description of iOCT use in paediatric vitreoretinal surgery	Review
16. Boral et al. A novel video overlay guided enlargement of area of ILM peeled versus inverted flap technique: A long-term study in large macular holes. European Journal of Ophthalmology 2021; 31: 3277–3283.		127 cases of large FTMH Comparison of video overlay guided enlargement of area of ILM peeled vs. inverted flap technique	Another main topic
17. Tao et al. Macular hole edge morphology predicts restoration of postoperative retinal microstructure and functional outcome. BMC Ophthalmology 2020; 20: 280.	53 MH patients Retrospective
18. Singh et al. Microscope-Integrated Optical Coherence Tomography-Guided Autologous Full-Thickness Neurosensory Retinal Autograft for Large Macular Hole-Related Total Retinal Detachment. Retina 2020; 10: 10.		2 eyes Neurosensory retinal autograft for large MH associated with retinal detachment	Cohort < 8
19. Pujari et al. Intraoperative optical coherence tomography guided ocular surgeries: Critical analysis of clinical role and future perspectives. Clinical Ophthalmology 2020; 14: 2427–2440.		Review	Review
20. Posarelli et al. What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review. Journal of Clinical Medicine 2020; 9: 02.		Systematic review iOCT in ophthalmic surgery	Systematic review
21. Lorusso et al. Feasibility and Safety of Intraoperative Optical Coherence Tomography-Guided Short-Term Posturing Prescription after Macular Hole Surgery. Ophthalmic Research 2020; 63: 18–24.	29 patients iOCT in MH surgery retrospective Outcomes: -closure rate -BCVA -time of positioning
22. Boral et al. A novel standardized reproducible method to calculate the area of internal limiting membrane peeled intra-operatively in macular hole surgery by using a video overlay-A long-term study in cases of idiopathic macular holes. Indian Journal of Ophthalmology 2020; 68: 157–161.		The study does not use iOCT.	Another main topic
23. Lytvynchuk et al. Dynamic intraoperative optical coherence tomography for inverted internal limiting membrane flap technique in large macular hole surgery. Graefes Archive for Clinical & Experimental Ophthalmology 2019; 257: 1649–1659.	8 eyes Prospective Non-randomized Observational ILM-flap technique Larger macular holes
24. Itoh et al. Alterations of Foveal Architecture during Vitrectomy for Myopic Retinoschisis Identified by Intraoperative Optical Coherence Tomography. Ophthalmologica 2019; 242: 87–97.		Myopic retinoschisis	Another main topic
25. Inoue et al. Intraoperative OCT Findings May Predict Postoperative Visual Outcome in Eyes with Idiopathic Macular Hole. Ophthalmology Retina 2019; 3: 962–970.	33 eyes with MH Retrospective Case-control study Outcomes: -Residual fragments -postop VA
26. Greven and Sanislo. Intraoperative Optical Coherence Tomography Demonstrating Macular Hole Associated With Ruptured Retinal Arterial Macroaneurysm. Ophthalmic Surgery, Lasers & Imaging Retina 2019; 50: e125-e127.		Case report	Case report
27. Ehlers et al. Predictive Model for Macular Hole Closure Speed: Insights From Intraoperative Optical Coherence Tomography. Translational Vision Science & Technology 2019; 8: 18.	37 eyes with FTMH Post-hoc analysis PIONEER study
28. Borrelli et al. Intraoperative optical coherence tomography in the full-thickness macular hole surgery with internal limiting membrane inverted flap placement. International Ophthalmology 2019; 39: 929–934.		3 patients FTMH iOCT used to confirm ILM flap positioning	Cohort < 8
29. Runkle et al. Factors Associated with Development of Dissociated Optic Nerve Fiber Layer Appearance in the Pioneer Intraoperative Optical Coherence Tomography Study. Retina 2018; 38: S103-S109.	95 eyes Post hoc PIONEER Dissociated optic-nerve-fiber layer (DONFL) and intraoperative membrane-peeling dynamics
30. Leisser et al. Diagnostic precision of a microscope-integrated intraoperative OCT device in patients with epiretinal membranes. European Journal of Ophthalmology 2018; 28: 329–332.		41 eyes ERM, LMH, VMT	Another main topic
31. Kumar and Yadav. HOLE-DOOR SIGN: A Novel Intraoperative Optical Coherence Tomography Feature Predicting Macular Hole Closure. Retina 2018; 38: 2045–2050.	25 patients with MH Outcomes -BCVA -preop hole diameter -type of hole closure Hole-door sign
32. Kumar and Yadav. A novel intraoperative optical coherence tomography feature predicting macular hole closure. Retina 2018; 38: 2045–2050.			Duplicate
33. Gonzalez-Cortes et al. Anatomical Changes of Full-Thickness Macular Hole Documented by Microscope-Integrated Spectral-Domain Optical Coherence Tomography. Ophthalmic Surgery, Lasers & Imaging Retina 2018; 49: e105–e111.		5 eyes with FTHM	Cohort < 8
34. Ehlers et al. THE INTEGRATIVE SURGICAL THEATER: Combining Intraoperative Optical Coherence Tomography and 3D Digital Visualization for Vitreoretinal Surgery in the DISCOVER Study. Retina 2018; 38: S88–S96.		7 eyes, which of 2 MH	Cohort < 8
35. Comparison of retinal architectural changes using intraoperative optical coherence tomography in macular hole surgery- a prospective randomized trial. 2018. Available online: https://trialsearchwhoint/Trial2aspx?TrialID=CTRI/2018/05/014219 (accessed on 18 August 2022).		Undergoing prospective randomized trial	Protocol
36. Bruyere et al. Benefit of Intraoperative Optical Coherence Tomography for Vitreomacular Surgery in Highly Myopic Eyes. Retina 2018; 38: 2035–2044.	Highly myopic eyes 22 eyes (10 MH)
37. Uchida et al. Analysis of Retinal Architectural Changes Using Intraoperative OCT Following Surgical Manipulations With Membrane Flex Loop in the DISCOVER Study. Investigative Ophthalmology & Visual Science 2017; 58: 3440–3444.	34 eyes (21 FTMH) DISCOVER Acute retinal alternations after ILM peeling with membrane flex loop
38. Sawaguchi et al. Macular Hole Formation Identified with Intraoperative Oct during Vitrectomy for Vitreomacular Traction Syndrome. RETINAL Cases & Brief Reports 2017; 11: 380–382.		Case report	Case report
39. Runkle et al. Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study. Ophthalmic Surgery, Lasers & Imaging Retina 2017; 48: 216–222.		50 eyes (6 FTMH) EnFocus prototype iOCT	Another main topic
40. Read and Fortun. Visualization of the retina and vitreous during vitreoretinal surgery: new technologies. Current Opinion in Ophthalmology 2017; 28: 238–241.		Review	Review
41. Ravani et al. Intravitreal cysticercosis with full thickness macular hole: management outcome and intraoperative optical coherence tomography features. BMJ Case Reports 2017; 21: 21.		Case report	Case report
42. Kumar et al. Utility of microscope-integrated optical coherence tomography (MIOCT) in the treatment of myopic macular hole retinal detachment. BMJ Case Reports 2017; 14: 14.		Case report	Case report
43. Jenkins et al. Intraoperative Optical Coherence Tomography of Internal Limiting Membrane Flap. Ophthalmology 2017; 124: 1456.		Photo essay Case report	Case report
44. Viehland et al. Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT. Biomedical Optics Express 2016; 7: 1815–1829.		Description	Review
45. Moisseiev and Yiu. Role of Tractional Forces and Internal Limiting Membrane in Macular Hole Formation: Insights from Intraoperative Optical Coherence Tomography. Case Reports in Ophthalmology 2016; 7: 372–376.		Case report	Case report
46. Khan and Ehlers. Clinical utility of intraoperative optical coherence tomography. Current Opinion in Ophthalmology 2016; 27: 201–209.		Review	Review
47. He and Sodhi. Intraoperative optical coherence tomography demonstrates immediate closure of a traumatic macular hole. Canadian Journal of Ophthalmology 2016; 51: e79–e81.		Case report	Case report
48. Branchini et al. Use of Handheld Intraoperative Spectral-Domain Optical Coherence Tomography in a Variety of Vitreoretinal Diseases. Ophthalmic Surgery, Lasers & Imaging Retina 2016; 47: 49–54.		5 cases	Cohort < 8
49. Riazi-Esfahani et al. Macular Surgery Using Intraoperative Spectral Domain Optical Coherence Tomography. Journal of Ophthalmic & Vision Research 2015; 10: 309–315.	16 patients with MH Qualitative finding Quantitative measures
50. Kunikata and Nakazawa. Intraoperative Optical Coherence Tomography-Assisted 27-Gauge Vitrectomy in Eyes with Vitreoretinal Diseases. Case Reports in Ophthalmology 2015; 6: 216–222.		6 patients with retinal disease	Cohort < 8
51. Hahn et al. Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device. Translational Vision Science & Technology 2015; 4: 1.		10 cases (2 FTMH)	Another main topic
52. Falkner-Radler et al. Intrasurgical Microscope-Integrated Spectral Domain Optical Coherence Tomography-Assisted Membrane Peeling. Retina 2015; 35: 2100–2106.	70 patients (8 LMH, 8 FTMH) Prospective study
53. Jprn. Intraoperative evaluation of the retina and intraocular tissue in the treatment of vitreoretinal surgery. 2014. Available online: https://trialsearchwhoint/Trial2aspx?TrialID=JPRN-UMIN000012822 (accessed on 18 August 2022).		Ongoing study	Protocol
54. Ehlers et al. Intrasurgical dynamics of macular hole surgery: an assessment of surgery-induced ultrastructural alterations with intraoperative optical coherence tomography. Retina 2014; 34: 213–221.	19 eyes with MH Retrospective Outcomes -MH volume -minimum diameter -base area -hole hight No functional analysis
55. Ehlers et al. The value of intraoperative optical coherence tomography imaging in vitreoretinal surgery. Current Opinion in Ophthalmology 2014; 25: 221–227.		Review	Review
56. Ehlers et al. Utility of intraoperative optical coherence tomography during vitrectomy surgery for vitreomacular traction syndrome. Retina 2014; 34: 1341–1346.		VMT surgery	Another main topic
57. Ehlers et al. Factors associated with persistent subfoveal fluid and complete macular hole closure in the PIONEER study. Investigative Ophthalmology & Visual Science 2014; 56: 1141–1146.	PIONEER study36 patients with surgically closed MH Outcomes -MH area + volume -EZ-RPE height -subretinal hyperreflectivity -postop subfoveal fluid
58. Hahn et al. Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device. Retina 2013; 33: 1328–1337.		Report of the translation of iOCT from preclinical testing into human imaging	Review
59. Pichi et al. Intraoperative SD-OCT in macular surgery. Ophthalmic Surgery, Lasers & Imaging 2012; 43: S54–S60.		5 eyes	Cohort < 8
60. Ray et al. Intraoperative microscope-mounted spectral domain optical coherence tomography for evaluation of retinal anatomy during macular surgery. Ophthalmology 2011; 118: 2212–2217.	25 eyes (MH 11/ERM) Retrospective
61. Hayashi et al. Intraoperative changes in idiopathic macular holes by spectral-domain optical coherence tomography. Case Reports in Ophthalmology 2011; 2: 149–154.		5 eyes	Cohort < 8
62. Ehlers et al. Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging. Investigative Ophthalmology & Visual Science 2011; 52: 3153–3159.		Not specific to MH, general retinal surgery	Another main topic
63. Binder et al. Feasibility of intrasurgical spectral-domain optical coherence tomography. Retina 2011; 31: 1332–1336.		4 MH	Cohort < 8
64. Wykoff et al. Intraoperative OCT of a full-thickness macular hole before and after internal limiting membrane peeling. Ophthalmic Surgery, Lasers & Imaging 2010; 41: 7–11.		Case report	Case report
65. Dayani et al. Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery. Retina 2009; 29: 1457–1468.		Only 4 eyes with MH 8 patients (4 MH, 3 ERM, 1 VMT) Prospective, observational case series	Another main topic