Table 1.
The role of OGN in cancer.
| Cancer Type | Expression (Protein/mRNA) | Level of Expression | Role | Function in Cancer | Ref. |
|---|---|---|---|---|---|
| Colon cancer | Protein | Downregulated | Tumor suppressor | Suppressing invasion, migration, and EMT and prolonging OS | [86] |
| Colon cancer | Protein | Downregulated | Tumor suppressor | Enhancing T iymphocytes infiltrating | [20] |
| Breast Cancer | mRNA/Protein | Downregulated | Tumor suppressor | Inhibiting cell proliferation, invasiveness, and EMT and prolonging OS | [90] |
| Liver cancer | Protein | Downregulated | Tumor suppressor | Decreasing metastatic potential to peripheral lymph nodes and prolonging OS | [90] |
| Cervical cancer | mRNA/Protein | Downregulated | Tumor suppressor | Suppressing proliferation, migration, and invasion and reversing EMT | [49] |
| Ovarian cancer | mRNA/Protein | Upregulated | Oncogene | Being associated with EMT and poor prognosis | [85] |
| Meningioma | mRNA/Protein | Upregulated | Oncogene | Accelerating proliferation | [87] |
| Melanoma | mRNA/Protein | Upregulated | Oncogene | Increasing cell death | [89] |