Table 4.
Hazard ratio (HR) values for cell populations from the best models influencing overall survival (OS) and disease-specific survival (DSS).
| Models Including HPV Status, IHC Markers Evaluated with Respect to the Stromal or Parenchymal Location. | |||
|---|---|---|---|
| OS | DSS | ||
| BIC = 308.96 | HR (p value) | BIC = 169.16 | HR (p value) |
| HPV RNA+ | 0.26 (0.0003) | HPV RNA+ | 0.15 (0.0011) |
| Increasing tumor stage | 1.55 (0.0179) | CD3+CD4+/Treg ratio | 3.18 (0.0016) |
| Parenchymal PD1+CD8+ T | 0.53 (0.0003) | Stromal PD1+CD8+ T | 0.44 (0.0007) |
| Models including HPV status, the IHC markers counted regardless of location. | |||
| OS | DSS | ||
| BIC = 307.31 | HR (p value) | BIC = 171.50 | HR (p value) |
| HPV RNA+ | 0.26 (0.0004) | HPV RNA+ | 0.22 (0.0057) |
| Increasing tumor stage | 1.57 (0.0160) | CD3+ T | 2.79 (0.0094) |
| PD1+CD8+ T | 0.52 (0.0001) | PD1+CD8+ T | 0.36 (0.0001) |
| Models without HPV status inclusion, the IHC markers evaluated with respect to the stromal or parenchymal location. | |||
| OS | DSS | ||
| BIC = 313.13 | HR (p value) | BIC = 174.57 | HR (p value) |
| Smoking (No) | 0.37 (0.0055) | Increasing age | 0.93 (0.0032) |
| Increasing tumor size | 1.44 (0.0709) | Stromal CD8+ T | 2.19 (0.0165) |
| Parenchymal PD1+CD8+ T | 0.52 (0.0003) | Stromal PD1+CD8+ T | 0.30 (0.0000) |