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. 2022 Oct 25;10(11):2700. doi: 10.3390/biomedicines10112700

Table 15.

Clinical trials targeting IL-5 in AD.

Target Molecule Clin Trial Gov Type of Study Status
IL-5
Anti-IL-5 monoclonal antibody
mepolizumab
NCT03055195 Phase II for AD Terminated (This study reached the pre-determined futility criteria following interim analysis. No safety concerns were noted)
IL-5Rα
Benralizumab
Monoclonal antibody anti-IL-5Rα
NCT03563066 Phase II for AD Completed
Benralizumab
Monoclonal antibody anti-IL-5Rα
NCT04605094 Phase II for AD Active, not recruiting