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. 2022 Nov 10;14(22):5539. doi: 10.3390/cancers14225539

Figure 2.

Figure 2

Small molecule inhibition of USP7 and its effect on anti-tumor immune response: (A) Initiation of p53-dependent apoptosis in tumor cells via p53/MDM2 pathway. (B) Decreasing PD-L1 levels sensitize tumor cells to T cell-mediated cytotoxicity by reducing PD-L1 interaction with PD-1. (C) Overcoming the immune tolerance of tumor via lowering IL-10 levels. (D) Reducing immunosuppressive functions of Tregs via destabilization of Tip60 and Foxp3. (E) Promotion of local anti-tumor immune response in tumor microenvironment via polarization of macrophage phenotype from anti-inflammatory M2 to proinflammatory M1.