Figure 2.

Selection of functional annotation terms enriched at 5% and 18% O₂ in (A) LNCaP, (B) Huh-7, (C) PC-3, and (D) SH-SY5Y cells. GO, gene ontology; CC, cellular component; MF, molecular function; KEGG, Kyoto encyclopedia of genes and genomes. (* p_adj < 0.05, ** p_adj < 0.005, otherwise p < 0.05). Other abbreviations: BMP, bone morphogenetic protein; EIF2AK1, eukaryotic translation initiation factor 2 alpha kinase 1; HRI, heme-regulated inhibitor; SMAD, SMA (small)—mothers against decapentaplegic; TCA, tricarboxylic acid; TGF, transforming growth factor.