Table 2.
Mitochondrially-encoded genes differentially expressed at 18% versus 5% O2.
| Gene Symbol | Gene Name | Description/Role | Log2FC † |
|---|---|---|---|
| LNCaP | |||
| MT-TL2 | Mitochondrially encoded tRNA leucine 2 (CUN) | Transfer RNA for leucine | −1.21 |
| MT-TW | Mitochondrially encoded tRNA tryptophan | Transfer RNA for tryptophan | +1.82 |
| Huh-7 | |||
| MT-ND1 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Complex I subunit | +1.36 |
| MT-CO1 | Mitochondrially encoded cytochrome c oxidase I | Complex IV subunit | +1.07 |
| MT-CO2 | Mitochondrially encoded cytochrome c oxidase II | Complex IV subunit | +1.19 |
| MT-CO3 | Mitochondrially encoded cytochrome c oxidase III | Complex IV subunit | +1.13 |
| MT-ATP6 | Mitochondrially encoded ATP synthase membrane subunit 6 | ATP synthase subunit | +1.07 |
| MT-ATP8 | Mitochondrially encoded ATP synthase membrane subunit 8 | ATP synthase subunit | +1.03 |
| MT-TY * | Mitochondrially encoded tRNA tyrosine | Transfer RNA for tyrosine | +1.94 |
| MT-TL1 | Mitochondrially encoded tRNA leucine 1 (UUA/G) | Transfer RNA for leucine | +1.44 |
| MT-TV | Mitochondrially encoded tRNA valine | Transfer RNA for valine | +2.07 |
| MT-TW | Mitochondrially encoded tRNA tryptophan | Transfer RNA for tryptophan | +3.14 |
| MT-TT | Mitochondrially encoded tRNA threonine | Transfer RNA for threonine | +1.00 |
| PC-3 | |||
| MT-ND2 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Complex I subunit | −1.08 |
| MT-ND4 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Complex I subunit | −1.04 |
| MT-ND4L | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L | Complex I subunit | −1.14 |
| MT-ND5 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Complex I subunit | −1.01 |
| MT-ND6 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Complex I subunit | −1.04 |
| MT-CYB | Mitochondrially encoded cytochrome b | Complex III subunit | −1.07 |
| MT-CO2 | Mitochondrially encoded cytochrome c oxidase II | Complex IV subunit | −1.01 |
| MT-ATP8 | Mitochondrially encoded ATP synthase membrane subunit 8 | ATP synthase subunit | −1.18 |
| MT-TA | Mitochondrially encoded tRNA alanine | Transfer RNA for alanine | −3.33 |
| MT-TL1 | Mitochondrially encoded tRNA leucine 1 (UUA/G) | Transfer RNA for leucine | −1.07 |
| MT-TM | Mitochondrially encoded tRNA methionine | Transfer RNA for methionine | −2.29 |
| SH-SY5Y | |||
| MT-ND3 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Complex I subunit | −1.13 |
| MT-ND5 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Complex I subunit | −1.02 |
| MT-ND6 | Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Complex I subunit | −1.01 |
| MT-ATP8 | Mitochondrially encoded ATP synthase membrane subunit 8 | ATP synthase subunit | −1.07 |
| MT-TH | Mitochondrially encoded tRNA histidine | Transfer RNA for histidine | −2.01 |
| MT-TE | Mitochondrially encoded tRNA glutamic acid | Transfer RNA for glutamate | −1.99 |
| MT-TG | Mitochondrially encoded tRNA glycine | Transfer RNA for glycine | −1.31 |
| MT-TQ | Mitochondrially encoded tRNA glutamine | Transfer RNA for glutamine | −6.27 |
| MT-TT | Mitochondrially encoded tRNA threonine | Transfer RNA for threonine | −1.38 |
| MT-TS2 | Mitochondrially encoded tRNA serine 2 (AGU/C) | Transfer RNA for serine | −1.27 |
* padj < 0.05, otherwise p < 0.05. † Positive value means gene is upregulated at 18% O2 while negative value indicates upregulation at 5% O2.