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. 2022 Nov 3;12(11):1493. doi: 10.3390/brainsci12111493

Figure 4.

Figure 4

The effects of PNU120596 (PNU, 1 mg/kg) in combination with memantine (MEM, 1 mg/kg) on LPS-induced depressive-like behavior. (A) Experimental timeline for drug administrations and behavioral assays. (B) The effect of PNU with MEM on total distance traveled (m). The two drugs did not show significantly alter the total distance traveled. (C) The effect of PNU with MEM on spontaneous alternations (%) in Y-maze. Treatment with PNU and MEM together significantly (p < 0.01) increased spontaneous alternations compared to the LPS-treated group. (D) Coadministration of PNU and MEM significantly (p < 0.01) decreased immobility time compared to the LPS-treated mice. (E) Coadministration of PNU and MEM significantly (p < 0.01) decreased immobility time in the FST than the LPS-treated mice. # p < 0.05, ## p < 0.01 or ### p < 0.001, vehicle/LPS (1 mg/kg) vs. vehicle/control; ** p < 0.01, PNU (1 mg/kg) + MEM (1 mg/kg)/LPS vs. vehicle/LPS. Data are expressed as mean ± SEM, n = 6–10/group.