Figure 18.

Schematic of lung-on-a-chip platform presented by Zhu et al. to develop favourable biomimetic breathing human lung with microphysiological breathing monitoring. (a) Figure of pulmonary alveolus while breathing. (b) Design of the developed breathing human-lung-on-a-chip device consisting of an array of pulmonary-alveolus-like structures. Rhythmic stretch during breathing was mimicked by cyclic airflow. Utilization of structural colours was enhanced to visualize breathing process. Fb = fibrinogen; NP = nanoparticle; AC = alveolar cell. Reprinted with permission from ref. [390], Copyright 2022, Wiley Online Library.