Table 3.
Relative risk (RR) and 95% confidence interval (95% CI) estimated for the association between resistin concentrations and the risk of colorectal cancer in the EPIC study data (1992–2005) in conditional logistic regression models.
| Quartile Form | Continuous Form | ||||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | p-Trend a | Doubling Resistin Concentrations b | p-Value | |
| Resistin quartile ranges (ng/mL) | 3.47 | 3.47< to 4.28 | 4.28< to 5.42 | 5.42< to 34.41 | |||
| Colorectal Cancer | |||||||
| No. cases/controls | 297/324 | 317/325 | 348/321 | 331/323 | 1293/1293 | ||
| Model 1 | ref | 1.06 (0.85–1.32) | 1.19 (0.95–1.49) | 1.13 (0.90–1.41) | 0.46 | 1.11 (0.95–1.30) | 0.19 |
| Model 2 | ref | 1.10 (0.88–1.37) | 1.22 (0.97–1.53) | 1.15 (0.91–1.46) | 0.38 | 1.12 (0.95–1.31) | 0.18 |
| Model 3 | ref | 1.11 (0.88–1.39) | 1.21 (0.97–1.53) | 1.15 (0.91–1.46) | 0.41 | 1.11 (0.94–1.30) | 0.22 |
| Colon Cancer | |||||||
| No. cases/controls | 165/174 | 178/193 | 203/188 | 211/202 | 757/757 | ||
| Model 1 | ref | 0.97 (0.73–1.30) | 1.16 (0.86–1.56) | 1.11 (0.83–1.50) | 0.62 | 1.14 (0.94–1.40) | 0.19 |
| Model 2 | ref | 1.01 (0.75–1.37) | 1.17 (0.86–1.59) | 1.15 (0.84–1.56) | 0.67 | 1.15 (0.93–1.42) | 0.19 |
| Model 3 | ref | 1.04 (0.76–1.41) | 1.20 (0.88–1.65) | 1.20 (0.88–1.65) | 0.53 | 1.18 (0.95–1.47) | 0.13 |
| Rectal Cancer | |||||||
| No. cases/controls | 120/134 | 119/115 | 127/118 | 109/108 | 475/475 | ||
| Model 1 | ref | 1.15 (0.81–1.64) | 1.20 (0.85–1.71) | 1.13 (0.78–1.64) | 0.76 | 1.07 (0.82–1.39) | 0.62 |
| Model 2 | ref | 1.17 (0.81–1.68) | 1.26 (0.88–1.82) | 1.20 (0.81–1.76) | 0.64 | 1.09 (0.83–1.43) | 0.55 |
| Model 3 | ref | 1.16 (0.80–1.68) | 1.25 (0.86–1.80) | 1.17 (0.79–1.73) | 0.69 | 1.06 (0.80–1.41) | 0.66 |
Model 1: Conditioned on matching factors only: age, sex, study center, time of the day at blood collection, and fasting status. Women were further matched by menopausal status, phase of the menstrual cycle, and use of oral contraceptives at blood collection, and postmenopausal women were matched by hormone replacement therapy use. Model 2: Model 1 + smoking status, education, alcohol consumption, alcohol abstainers, physical activity index, energy intake, red meat, processed meat, dietary fiber, fruit intake, vegetable intake, dairy intake, fish, and shellfish intake. Model 3: Model 2 + body mass index (BMI), and residuals of BMI-adjusted waist circumference. a p-values for trend derived from models with the median resistin concentration within quartiles as a continuous variable. b Models with continuous log-transformed resistin concentrations by log 2.