Table 4.
Relative risk (RR) and 95% confidence interval (95% CI) estimated for the association between resistin concentrations and the risk of colorectal cancer stratified by sex and subsite in the EPIC study data (1992–2005) in conditional logistic regression models.
| Quartile Form | Continuous Form | ||||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | p-Trend a | Doubling Resistin Concentrations b | p-Value | |
| Resistin quartile ranges (ng/mL) | 3.47 | 3.47< to 4.28 | 4.28< to 5.42 | 5.42< to 34.41 | |||
| Sex | |||||||
| Women | |||||||
| No. cases/controls | 134/154 | 165/183 | 190/157 | 192/187 | 681/681 | ||
| RR (95% CI) | ref | 1.02 (0.75–1.40) | 1.39 (1.00–1.94) | 1.21 (0.87–1.67) | 0.17 | 1.06 (0.85–1.33) | 0.59 |
| Postmenopausal women | |||||||
| No. cases/controls | 97/120 | 123/129 | 136/110 | 135/132 | 491/491 | ||
| RR (95% CI) | ref | 1.14 (0.79–1.63) | 1.48 (1.01–2.18) | 1.25 (0.85–1.84) | 0.25 | 1.12 (0.86–1.47) | 0.38 |
| Men | |||||||
| No. cases/controls | 163/170 | 152/142 | 158/164 | 139/136 | 612/612 | ||
| RR (95% CI) | ref | 1.20 (0.85–1.69) | 1.05 (0.76–1.47) | 1.08 (0.76–1.54) | 0.77 | 1.14 (0.89–1.46) | 0.29 |
| Sex and Tumor subsite | |||||||
| Colon cancer women | |||||||
| No. cases/controls | 77/93 | 99/108 | 120/103 | 133/125 | 429/429 | ||
| RR (95% CI) | ref | 1.11 (0.73–1.68) | 1.40 (0.91–2.16) | 1.37 (0.89–2.11) | 0.37 | 1.17 (0.88–1.57) | 0.28 |
| Colon cancer men | |||||||
| No. cases/controls | 88/81 | 79/85 | 83/85 | 78/77 | 328/328 | ||
| RR (95% CI) | ref | 0.96 (0.59–1.55) | 0.97 (0.60–1.59) | 0.95 (0.58–1.57) | 1.00 | 1.13 (0.80–1.58) | 0.50 |
| Rectal cancer women | |||||||
| No. cases/controls | 54/53 | 55/65 | 62/50 | 53/56 | 224/224 | ||
| RR (95% CI) | ref | 0.70 (0.41–1.19) | 1.11 (0.62–2.00) | 0.72 (0.40–1.31) | 0.29 | 0.71 (0.46–1.08) | 0.11 |
| Rectal cancer men | |||||||
| No. cases/controls | 66/81 | 64/50 | 65/68 | 56/52 | 251/251 | ||
| RR (95% CI) | ref | 1.89 (1.06–3.36) | 1.43 (0.85–2.40) | 1.8 (0.99–3.24) | 0.12 | 1.53 (1.01–2.33) | 0.05 |
Results were based on conditional logistic regression models conditioned on matching factors (age, sex, study center, time of the day at blood collection, and fasting status, women were further matched by menopausal status, phase of the menstrual cycle, and use of oral contraceptives at blood collection, and postmenopausal women were matched by hormone replacement therapy use) and adjusted for smoking status, education, alcohol consumption, alcohol abstainers, physical activity index, energy intake, red meat, processed meat, dietary fiber, fruit intake, vegetable intake, dairy intake, fish and shellfish intake, body mass index (BMI), and residuals of BMI-adjusted waist circumference. a p-values for trend derived from models with the median resistin concentration within quartiles as continuous variables. b Models with continuous log-transformed resistin concentrations by log 2.