Table 4.

Correlation matrix for serum SAA in SONIA 2 patients at the end of study (year 4). Spearman’s r and p values are reported, and statistically significant correlations highlighted in bold. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001.

Source	Indicator	r	P
	age	−0.0278	ns
	BMI	0.369	*** <0.0001
HAQ	hapvas	0.136	ns
	haqdi	0.360	*** 0.0001
SF-36	physical	−0.283	** 0.0030
	mental	0.0320	ns
KOSS	pain	−0.170	ns
	symptoms	−0.180	ns
	ADL	−0.247	* 0.0102
	sport	−0.231	* 0.0175
	QoL	−0.227	* 0.0188
AKUSSI	joint pain	0.0445	ns
	spinal pain	−0.089	ns
	eye pigment	0.309	** 0.0012
	ear pigment	0.072	ns
	ostearticular disease joints	0.194	ns
	ostearticular disease spine	0.101	ns
	cAKUSSI	0.181	ns
metabolites	sHGA	−0.061	ns
	u24HGA	−0.078	ns
	sTyr	0.141	ns

Abbreviations: ns: not significant; hapvas: HA visual analog scale; haqdi: HA disability index; ADL: activities of daily living; QoL: quality of life. sHGA: serum HGA; u24HGA: 24 h urinary HGA; sTyr: serum Tyrosine.