Figure 1.

Schematic presentation of the CD36 structure. CD36 harbours two transmembrane domains in a large extracellular region containing ligand-binding sites. CD36 has two cytoplasmic tails (N-terminal and C-terminal) that contains four palmitoylation sites. The C-terminus contains two ubiquitination sites. The large extracellular loop contains 10 N-linked glycosylation sites and two phosphorylation sites. CD36 also contains three disulphide bonds between extracellular cysteines. In addition, the hydrophobic pocket is involved in ligand binding and serves as a tunnel through which hydrophobic ligands are transported from the extracellular space across the phospholipid membrane bilayer. Arrowhead and numbers denote the approximate position of amino acid residues.