Table 2.
Association of immune-related molecules with therapy method and response.
| Variables | Therapy Method | p | Tumor Regression Grade | p | |||||
|---|---|---|---|---|---|---|---|---|---|
| nCT | nCRT | TRG 0 | TRG 1 | TRG 2 | TRG 3 | ||||
| CTLA-4+ cells | Low | 54 (50.9) | 75 (50.3) | 0.924 | 26 (52.0) | 45 (55.6) | 42 (51.2) | 16 (38.1) | 0.324 |
| High | 52 (49.1) | 74 (49.7) | 24 (48.0) | 36 (44.4) | 40 (48.8) | 26 (61.9) | |||
| CD86+ cells | Low | 85 (80.2) | 134 (89.9) | 0.028 * | 47 (94.0) | 72 (88.9) | 67 (81.7) | 33 (78.6) | 0.096 |
| High | 21 (19.8) | 15 (10.1) | 3 (6.0) | 9 (11.1) | 15 (18.3) | 15 (21.4) | |||
| tCD4+ cells | Low | 85 (88.5) | 106 (97.2) | 0.014 * | 0 | 79 (97.5) | 77 (93.9) | 35 (83.3) | 0.012 * |
| High | 11 (11.5) | 3 (2.8) | 0 | 2 (2.5) | 5 (6.1) | 7 (16.7) | |||
| NA | 10 | 40 | 50 | 0 | 0 | 0 | |||
| sCD4+ cells | Low | 41 (38.7) | 85 (57.0) | 0.004 * | 31 (62.0) | 45 (55.6) | 37 (45.1) | 13 (31.0) | 0.013 * |
| High | 65 (61.3) | 64 (43.0) | 19 (38.0) | 36 (44.4) | 45 (54.9) | 29 (69.0) | |||
| iCD4+ cells | Low | 52 (49.1) | 115 (77.2) | 0.000 * | 44 (88.0) | 61 (75.3) | 44 (53.7) | 18 (42.9) | 0.000 * |
| High | 54 (50.9) | 34 (22.8) | 6 (12.0) | 20 (24.7) | 38 (46.3) | 24 (57.1) | |||
| tCD8+ cells | Low | 58 (60.4) | 90 (82.6) | 0.000 * | 0 | 64 (79.0) | 58 (70.7) | 26 (61.9) | 0.124 |
| High | 38 (39.6) | 19 (17.4) | 0 | 17 (21.0) | 24 (29.3) | 16 (38.1) | |||
| NA | 10 | 40 | 50 | 0 | 0 | 0 | |||
| sCD8+ cells | Low | 51 (48.1) | 80 (53.7) | 0.380 | 33 (66.0) | 40 (49.4) | 35 (42.7) | 23 (54.8) | 0.069 |
| High | 55 (51.9) | 69 (46.3) | 17 (34.0) | 41 (50.6) | 47 (57.3) | 19 (45.2) | |||
| iCD8+ cells | Low | 79 (74.5) | 131 (87.9) | 0.006 * | 50 (100.0) | 67 (82.7) | 61 (74.4) | 32 (76.2) | 0.002 * |
| High | 27 (25.5) | 18 (12.1) | 0 (0.0) | 14 (17.3) | 21 (25.6) | 10 (23.8) | |||
| TRG | TRG 0 | 10 (9.4) | 40 (26.8) | 0.000 * | - | - | - | - | - |
| TRG 1 | 24 (22.6) | 57 (38.3) | - | - | - | - | |||
| TRG 2 | 35 (33.0) | 47 (31.5) | - | - | - | - | |||
| TRG 3 | 37 (34.9) | 5 (3.4) | - | - | - | - | |||
*, p < 0.05, statistically significant; the p value of 0.000 indicated p < 0.001.