Figure 2.

Macrophage development and functions in different organs. Tissue-resident macrophages are originated from the yolk sac/fetal liver and hematopoietic progenitors/circulating monocytes. Monocytes are further differentiated into M1-like and M2-like macrophages based on their expression markers upon a variety of stimuli. M2-like macrophages are known to be important for wound repair and also share similar features with TAMs. M1-like macrophages constitute the first line of defense against intracellular pathogens. Macrophages are sources of Wnt ligands and mediate Wnt ligand-mediated signaling for various immune responses for tissue inflammation and repair. This was created with Biorender.com.