Figure 4.

(A) Schematic illustration of the targeted theranostic platinum (IV) prodrug with a built-in aggregation-induced emission (AIE) light-up apoptosis sensor for noninvasive, in situ early evaluation of its therapeutic responses. Reprinted with permission from ref. [50]. Copyright 2014, American Chemical Society. (B) Schematic illustration showing the probe DFP for rapid drug delivery and drug release tracking in MMP-2 over-expression living cells. Reprinted with permission from ref. [51]. Copyright 2016, American Chemical Society. (C) Schematic illustration of TPR@DOX for tumor treatment and apoptosis monitoring. Reprinted with permission from Reference [52]. Copyright 2021, American Chemical Society. (D) Caspase-3/7-sensing mechanism of CP1. Reprinted with permission from ref. [53]. Copyright 2017, American Chemical Society.