Table 2.

Analytical performances of AIE-based methods for the detection of phosphatases.

Targets	Probes	Linear Range	LOD	Ref.
ALP	TPE-PA	0~0.1 U/mL	18 mU/mL	[58]
ALP	TPE-2PA	3~526 U/L	0.2 U/L	[59]
ALP	TPE-4PA	10~50 mU/mL	–	[60]
ALP	THP	0~200 U/L	1.21228 U/L	[61]
ALP	QMTP	0~1200 U/L	5.36 U/L	[62]
ALP	HCAP	0~150 mU/mL	0.15 mU/mL	[63]
ALP	FAS-P	1~100 U/L	0.6 U/L	[64]
ALP	TPEPy-DFDFPYDEGDK	1~106 CFU/mL	6.6 × 10−3 U/mL	[65]
ALP	TPE-Py-FpYGpYGpY	0~2 U/mL	–	[66]
ALP	PET-Flu-PO4/TPE	0~100 mU/mL	5 mU/mL	[67]
ALP	BSPOTPE-PrS	0~36 mU/mL	28.7 μU/mL	[68]
ALP	H4TCPE/SR101/Cu-GMP ICP	0.01~0.1 U/mL	0.0032 U/mL	[69]
ALP	GSH-capped CuNCs	0.5~25 mU/mL	0.15 mU/mL	[70]
ACP	CuNCs	2.2~100 U/L	0.8 U/L	[71]
ALP	P-Glu/CuNCs	0.56~30 U/L	0.17 U/L	[72]
ALP	PAH-AuNCs	0.5~100 U/L	0.2 U/L	[73]
ACP	GSH-AuNCs	0.005~2.4 U/L	0.001 U/L	[74]
PPase	AgNCs	2.1~35 U/L	0.7 U/L	[75]
PKM2	TEPC466	0~20 μg/mL	21.25 ng/mL	[76]

Abbreviations: ALP, alkaline phosphatase; TPE, tetraphenylethylene; PA, phosphate; THP, 2-(benzo[d]thiazol-2-yl)-4-(1,4,5-triphenyl-1H-imidazole-2-yl)phenyl dihydrogen phosphate; QMTP, the conjugate of quinolone–malononitrile and phosphate-modified thiophene; HCAP, phosphorylated conjugate of 2′-hydroxyacetophenone and 4-dimethylaminobenzaldehyde; FAS-P, (E)-2-(((9H-fluoren-9-ylidene) hydrazono)methyl) phenyl dihydrogen phosphate; BSPOTPE, 1,2-Bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene; pY, tyrosine phosphate; PrS, protamine sulphate; H4TCPE, 1,1,2,2-tetra(4-carboxylphenyl)ethylene; SR101, sulforhodamine 101; GMP, guanosine-5-monophosphate; P-Glu, D-glucose 6-phosphate; CuNCs, copper nanoclusters; GSH, glutathione; PAH, polyallylamine hydrochloride; AuNCs, gold nanoclusters; ACP, acid phosphatase; PPase, inorganic pyrophosphatases; PKM2, pyruvate kinase.