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Diagnostic performance of YKL-40 mRNA levels in CRC tissues (H) and YKL-40 protein levels in CRC serum. Receiver operating characteristic (ROC) curve analysis in (A) CRC tissue samples (n = 19) and colon mucosa derived from cancer-free subjects (n = 19); area under the curve (AUC) = 85.6 (95% CI: 73.7–97.4%, p = 0.0002); (B) tumor serum samples (n = 43) and serum samples derived from cancer-free subjects (n = 43); area under the curve (AUC) = 78.7 (95% CI: 69.0–88.4%, p = 0.000004).
