Table 2.

Potential multi-omics base transcriptomics biomarkers in CRC.

Biomarker	Sample Type	Change	Application	References
miR-92a, miR-21	serum	upregulated	diagnostic and prognostic	[91]
hsa_circ_0000567	CRC tissue and cell lines	downregulated	diagnostic	[92]
hsa-circ-0006282	plasma	upregulated	Diagnostic	[93]
hsa_circ_000592, hsa_circ_0001900 and hsa_circ_0001178	plasma	upregulated	diagnostic	[94]
miR-129-1-3p mmiR-566	urine	upregulated	detection	[95]
GPR55	CRC tissue and cell lines	downregulated	prognostic	[96]
miR-1290	plasma	upregulated	prognostic	[97]
miR-320d	plasma	downregulated	diagnostic	[98]
miR-103a-3p, miR-127-3p, miR-17-5p, miR151a5p, miR-181a-5p, miR-18a-5p and miR-18b-5p	plasma	upregulated	diagnostic	[99]
CCAT2, CCAT1, H19, MALAT1, MEG3, HULC, HOTAIR, PCAT1, PTENP1 and TUSC7	stool	upregulated	detection	[100]
miR-214, miR-199a-3p, miR-196a, miR-106a, miR-183, miR-134, miR-92a, miR-96, miR-20a, miR-21, miR-17, miR-7.	stool	upregulated	screening	[101]
miR-138, miR-143, miR-29b, miR-9, miR-146a, miR-127-5p, miR-938, miR-222.	stool	downregulated	screening	[101]