Table 3.
Potential multi-omics based proteomics biomarkers in CRC.
| Biomarker | Sample Type | Change | Application | References |
|---|---|---|---|---|
| CHD 9 | tissue | upregulated | prognostic | [117] |
| ACTBL2 | tissue | upregulated | diagnostic | [102] |
| CDK3, CDK5, and CDK8 | tissue | upregulated | diagnostic | [118] |
| STK4 or MST1 | serum | downregulated | detection | [119] |
| MRC1 and S100A90 | serum | upregulated | diagnostic | [114] |
| CEACAM-7 | tissue | downregulated | predictive | [120] |
| CEA | plasma | upregulated | predictive and prognostic | [121] |
| SPG20 and STK31 | blood | upregulated | diagnostic | [122] |
| TPM3 | tissue/plasma | upregulated | detection | [123] |
| FJX1 | serum | upregulated | prognostic and diagnostic | [124] |
| NOP14 | datasets | upregulated | Prognosis | [125] |
| SPARCL1 | datasets | Downregulated | diagnosis | [126] |