Figure 1.

Schematic diagram of the action mechanism employed by coding SNPs. (a) The A allele of the rs8100241 variant, which is found in the ANKLE1 second exon region, has been linked to a lower risk of CRC by increasing ANKLE1 mRNA m6A levels and thus facilitating ANKLE1 protein expression, thereby potentially functioning as a negative regulator to hinder cell growth by maintaining genomic stability. (b) Interaction between the TCF7L2 missense variant rs138649767 and a regulatory variant rs6983267 in the MYC enhancer and promoter on the expression of MYC.