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. 2022 Nov 12;11(22):3583. doi: 10.3390/cells11223583

Figure 6.

Figure 6

PGZ treatment is also effective on the dermal component. (A) The evaluation of gene expression of several anaerobic glycolytic enzymes induced by PGZ. (B) Significant glucose increase content in the medium of vitiligo fibroblasts. (C) IGFBP3 was downregulated in vitiligo fibroblasts by PGZ, both mRNA and protein levels. (D) Gene expression downregulation of senescence markers after 6 h of PGZ treatment. (E) The growth factors gene expression was analyzed by RT-PCR. The results were shown as a fold increase above the control. b-FGF and HGF were also assessed by Western blot. (F) The overexpression of Fibronectin was detected by RT-PCR and Western blot in vitiligo fibroblasts, respectively, after 6 and 48 h of PGZ treatment. (G) CD36 gene expression in vitiligo fibroblasts and melanocytes after PGZ treatment. The representative Western blot of CD36 total protein in vitiligo cell lines. All data are expressed as means ± SD of at least 3 independent experiments, * p ≤ 0.05 and ** p ≤ 0.01.