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TAS2R signal transduction cascade in smooth muscle cells. 1. Cytosolic calcium increases open BKCa, leading to the outflow of K+ and, consequently, to membrane hyperpolarization. 2. TAS2R Gβγ subunit inhibits VDCC activated by a procontractile stimulus. 3. TAS2Rs promote the mitochondrial uptake of calcium released, following challenge with a procontractile stimulus.
