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. 2022 Nov 11;11(22):3573. doi: 10.3390/cells11223573

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The mechanism of melatonin in reducing oxidative damages in vitrified oocytes. Melatonin can enter oocytes through receptors, act on the Nrf2 antioxidant signaling pathway, and enhance the expression of antioxidant enzymes, protect normal morphology and function of organelles such as mitochondria and the spindle, and ensure the correct segregation of meiotic chromosomes. Melatonin can also directly penetrate into cells to scavenge free radicals, reduce intracellular ROS, and improve the development potential of cells in vitro. Created with BioRender.com (accessed on 19 October 2022).