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. 2022 Nov 17;11(22):3640. doi: 10.3390/cells11223640

Figure 1.

Figure 1

In silico splice-site predictions for the c.11+5G>A variant of RPE65 by Alamut 2.13. Schematic representation of the RPE65 gene and enlargement of the exon 1 and intron 1 for both the wild-type sequence and for the c.11+5G>A variant. Four in silico predictions of different algorithms are indicated below each sequence. The blue triangles indicated the position of splice donor sites, which are separate 124 nt. In red, the nucleotide on position c.11+5 is indicated. In green, the prediction by SpliceAI (delta score). SSFL, SpliceSiteFinder-like; MES, MaxEntScan; NNS, NNSPLICE and GS, GeneSplicer.