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Wild-type TP53, but not TP53-p.Glu358Val, suppresses mitophagy by reducing PINK1 levels. (A) PINK1 mRNA levels. (B) Immunoblots of PINK1, ATP5A and tubulin protein levels. (C) Subcellular localization of TP53 in H2172 cells. DAPI is used to indicate the position of nucleus. Scale bar = 10 µm. (D) Quantification of TP53 fluorescence intensity in nucleus vs. cytoplasm. * p < 0.05, ** p < 0.01, *** p < 0.001.
