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IL-12-related signaling pathway. IL-12 is unique in having the only heterodimeric cytokines, which are composed of an α-chain (p35) and a β-chain (p40). IL-12 signals via its receptor IL-12RB1 and IL-12RB2 are mediated by members of the JAK-STAT family which mediate the expression of downstream proteins, such as IL-21, IL-17A, IL-23R, IL-18R, IL-2Rα, T-bet and IFN-γ.
