Figure 3.

IL-12 related irAE. In clinical trials of patients with cancer, hematologic toxicity, inflammatory liver steatosis, flu-like symptoms, mucus membrane inflammation, bone marrow hyperplasia are found the major side effects. In preclinical experiments with mouse tumor models, hematologic toxicity, inflammatory liver steatosis and muscle toxicity are seen. However, hypoproteinemia, hypophosphatemia, hypocalcemia, splenomegaly, enlarged lymph node and bone marrow hyperplasia are the most common irAE seen in squirrel monkeys.