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. 2022 Nov 9;11(22):3535. doi: 10.3390/cells11223535

Figure 2.

Figure 2

Accumulation of neutrophils and microglia in the SRS of mouse models. (a) Cells isolated from the SRS of 10 month old Cryba1 cKO (when the AMD-like phenotype is first observed in the Cryba1 cKO mouse model) and Akt2 KI mice showed increase in neutrophils (% neutrophils), compared to age matched floxed and WT mice. (b) Flow cytometric fluorescence plot and (c) quantification of microglia homeostatic marker, CX3CR1 (PerCpCy5.5-A mean fluorescence) showing diminished expression of the protein in microglia (CD45LowCD11b+Ly6C−Ly6G−) from the SRS of 10-month-old Cryba1 cKO and Akt2 KI mice, compared to controls. n = 3. ** p < 0.01.