Figure 4.

Female kidney status: (A) Kidneys isolated at day 70 after birth from WT and G9KO female mice under a control diet and inosine supplementation. Mice show severe morphological changes, which worsen under inosine supplementation. (B) Summary of total kidney weight (mean ± SEM) in WT (+/+) and KO (−/−) females. Inosine supplementation further reduces kidney weight in G9KO animals. (C) HE, F4/80, and CD3 stainings of WT (+/+) and KO (−/−) animals exposed to inosine during fetal development. Scale bar: 25 µm; * p < 0.05.