Table 1.

Summary of Parental PDX and Derivative PDX Therapy and Mutations.

Parental PDX	ID *	Therapy **	Genes Mutated	TMB Gain ***	MSH6 †	MSH2 †	MLH1 †	PMS2 †
GBM6	m4052	RT	20	2.10	0	0	0	0
	m4063		44	2.78	0	0	0	0
	m4066		21	1.24	0	0	0	0
GBM12	m6159		219	15.12	0	0	0	0
	m6161		205	15.63	0	0	0	0
GBM43	m3087		48	4.02	0	0	0	0
	m3098		27	1.30	0	0	0	0
GBM6	m4056	TMZ ×1	297	13.60	0	0	0	0
	m4057		249	9.80	0	0	0	0
	m4082		122	5.98	0	0	0	0
	m4883		280	17.59	0	0	0	0
GBM12	m2656		288	12.38	0	0	0	0
	m2657		302	16.67	0	0	0	0
GBM6	m3395	RT+TMZ ×1	78	3.69	2	0	0	0
	m4051		473	20.62	1	0	0	0
GBM12	m2671		463	22.36	2	0	0	0
	m2685		359	15.28	0	0	0	0
	m2511	RT+TMZ ×2	282	17.86	0	0	1	0
GBM6	m3378	RT+TMZ ×3	1403	65.98	1	0	0	1
GBM12	m4829	TMZ ×4	2238	105.78	2	1	0	0
	m4834		3021	151.85	3	1	0	1

* Identification number of individual derivative PDX. ** Therapy regimen for initial intracranial engraftment of PDX (see Figure 1A). *** Increase in tumor mutation burden (TMB), relative to matched parental PDX, measured in mutations per megabase (Mb) of DNA. ^† Number of mutations in each DNA mismatch repair (MMR) gene in each derivative PDX. RT = radiation therapy, TMZ = temozolomide cycle.