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Effects of APOE genotype on intracellular levels of Tau and pTau. Primary cortical neurons cultures were obtained from P0-P1 newborn KI mice carrying the human APOE3 or APOE4 alleles. After 12 days in culture, tau and p-tau levels were assessed in cell lysates using Western blot and normalization with actin levels. Statistics: Mann and Whitney test **: p < 0.01, comparison with APOE3, 3 independent cultures with 2 to 3 replicates per culture.
