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Lin28 inhibitors restore Let-7d expression and suppress SOX2 and HMGA2 genes. DUNE (top) and DUNE (KO) (bottom) cells were treated with 20 uM of the indicated compounds for 48 h. Real-time qPCR measured RNA levels of Let-7d, SOX2, and HMGA2. Three biological replicates were performed and all results are presented as mean +/− SD. p-value ≤ 0.05—(*); ≤0.01—(**); ≤0.001—(***).
