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CD36 plays a role in tumor immunity. CD36 mediates Ox-LDL uptake, promotes lipid peroxidation in CD8+T cells, phosphorylates p38 kinase, which in turn inhibits IFN-γ and TNF production. CD36 also activates PPAR-β signaling to enhance mitochondrial fitness of Treg cells in tumors. And CD36 promotes STAT6 phosphorylation to enhance mitochondrial fitness of TAMs, which in turn promotes tumor proliferation.
