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. 2022 Nov 15;11(22):3613. doi: 10.3390/cells11223613

Figure 5.

Figure 5

RNA sequencing analysis identifies activating G12D KRAS mutation in iCCAOs. (A) Simplified schematic overview of KRAS transcript variants with annotated lengths of corresponding PCR products. (B) Condensed overview of RNA sequencing analysis results for KRAS transcript variants in iCCAOs and ICOs. Red boxes indicate location of the detected activating G12D mutation and corresponding consensus sequence in non-mutated transcripts. Blue boxes indicate location of the detected silent D173D mutation and corresponding consensus sequence in non-mutated transcripts. Full sequences are listed in Table S1. Sequencing data were analyzed and visualized with Geneious Prime® (version 2021.1.1, Biomatters).