Table 3.
Timetable showing multimodality treatment of liver metastasis.
| Case #1 | Treatment | Comments | Liver Segments | Classification | Complications |
| 05.11.2018 | SRFA | 1 lesion, 13 cm, 6 needles, 47 min ablation time | V, VII, VIII | Initial | none |
| 29.11.2018 | SRFA | 1 lesion, 13 cm, 28 needles, 223 min ablation time | VIII | Initial | none |
| 11.12.2018 | SRFA | 1 lesion, 13 cm, 13 needles, 60 min ablation time | V, VII, VIII | Initial | none |
| 28.01.2019 | SRFA | 1 lesion, 13 cm, 15 needles, 43 min ablation time | V, VII, VIII | Initial | none |
| 01.03.2019 | SRFA | 1 lesion, 13 cm, 5 needles, 17 min ablation time | VIII | Local recurrence | none |
| 05.11.2020 | SRFA | 1 lesion, 13 cm, 12 needles, 59 min ablation time | VIII, V | Distant recurrence | none |
| Case #2 | Treatment | Comments | Liver Segments | Classification | Complications |
| 16.06.2015 | TAE | Embozene™ Microspheres (500 μm), Soft Embolization Coils (Boston Scientific), Pushable Fibered and Detachable Non-Fibered Microcoils (Cook Medical) | VII, VIII, II, III | Initial | none |
| 31.07.2015 | TAE | Embozene™ Microspheres (2 × 100 μm, 4 × 250 μm, 1 × 750 μm) | VII, VIII | Initial | Infection of necrotic liver tissue (CD II) |
| 22.09.2015 | TAE | Embozene™ Microspheres (4 × 100 μm, 2 × 250 μm, 2 × 400 μm) | V, VIII | Initial | Infection of necrotic liver tissue (CD II) |
| 01.12.2015 | Surgery | Right hemihepatectomy | V-VIII | Local recurrence | none |
| 15.02.2016 | SRFA + liver packing | 3 lesions, 3 cm max. diameter, 6 needles, 17 min ablation time | II | New lesions | none |
| 10.11.2016 | Surgery | 2 lesions, Resection S II + III, 6 h 47 min |
II, III | Local recurrence | none |
| 16.03.2017 | SRFA | 1 lesion, 2 cm max. diameter, 3 needles, 6 min ablation time | IVa | New lesion | none |
| 11.08.2017 | SRFA | 3 lesions, 0.8 cm max. diameter, 5 needles, 12 min ablation time | IVa | New lesions | none |
| 01.02.2018 | SRFA | 2 lesions, 1 cm max. diameter, 2 needles, 8 min ablation time | IVb | New lesions | none |
| 11.19–01.20 | Systemic therapy | Axitinib | New lesions, local recurrence | Progressive disease under therapy axitinib (new intracranial tumor 01/20) | |
| 09.06.2020 | Systemic therapy | Temozolomide, bevacizumab | New lesions | Progressive disease under therapy | |
| Case #3 | Treatment | Comments | Liver Segments | Classification | Complications |
| 05.05.2014 | TAE | Contour™ PVA Embolization Particles (255–500 μm), Pushable Fibered Microcoils (Cook Medical), Soft Embolization Coils (Boston Scientific), MicroPlex® Coil System (MicroVention, Inc.) | IVa, IVb, V, VI, VII | Initial | Postembolization syndrome (CD I) |
| 24.06.2014 | TAE | Contour™ PVA Embolization Particles (150–500 μm) | II, III | Initial | Postembolization syndrome (CD I) |
| 22.07.2014 | TAE | Contour™ PVA Embolization Particles (250–350 μm) | IVa, IVb, V, VI, VII | Initial | none |
| 10.11.2014 | TAE | Embozene™ Microspheres (2 × 100 μm) | IVa, IVb, V, VI, VII | Initial | none |
| 08.04.2015 | TAE | Embozene™ Microspheres (1 × 100 μm, 1 × 250 μm, 1 × 400 μm, 1 × 500 μm) | II, III | Initial | none |
| 06.05.2015 | TAE | Embozene™ Microspheres (1 × 100 μm, 1 × 200 μm) | IVa, IVb, V, VI, VII | Initial | none |
| 26.08.2015 | Surgery | Resection of left lateral segments | II + III | Initial | Bilioma (CD I) |
| 08.07.2016 | TAE | Embozene™ Microspheres (2 × 100 μm, 1 × 250 μm) | IVa, IVb, V, VI, VII | Local recurrence | none |
| 21.11.2016 | SRFA | 3 lesions, 5.1 cm max. diameter, 8 needles, 63 min ablation time | IVa, VII, VIII | Local recurrence | none |
| 07.12.2016 | SRFA | 2 lesions, 2.3 cm max. diameter, 4 needles, 59 min ablation time | IVa, VIII; | Local recurrence, new lesion | none |
| 26.01.2017 | SRFA | 2 lesions, 8 cm max. diameter, 9 needles, 74 min ablation time | VI | Local recurrence | Right pleural effusion, pigtail catheter (CD IIIa) |
| 23.03.2017 | SRFA | 2 lesions, 8 cm max. diameter, 20 needles, 104 min ablation time | V, VI | Local recurrence | none |
| 30.10.2017 | SRFA | 8 lesions, 2 cm max. diameter, 9 needles, 32 min ablation time | V, VI | Local recurrence, new lesion | none |
| 04.04.2018 | SRFA | 4 lesions, 2 cm max. diameter, 10 needles, 36 min ablation time | V, VI, VII, VIII | Local recurrence, new lesion | none |
| 05.19–08.19 | Systemic therapy | Pazopanib | Distant recurrence | Leukocytopenia, Infection, Sepsis CTCAE III |
CD, Clavien–Dindo; SRFA, stereotactic radiofrequency ablation; TAE, transarterial embolization.