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. 2022 Oct 25;29(11):7994–8018. doi: 10.3390/curroncol29110633

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The competing endogenous (ceRNA) network in CC and protein-protein interaction (PPI) network, as well as top 1 modules. (A) The circRNA-miRNA-mRNA ceRNA network, in where circRNAs, miRNAs, and mRNAs are represented as triangle, hexagon and circle, respectively. (B) The circRNA-miRNA-lncRNA ceRNA network, in where the expression level showed a high-low-high phenomenon. (C) protein-protein interaction (PPI) network. (D) Top 1 hub module was identified by Cytoscape plug-in MCODE. The size of the dots represents the regulatory capacity of the mRNA, and the larger dots, the stronger the regulatory capacity.