Table 7.
Predicted toxicity properties of the proposed pyrazole compounds.
| TOXICITY | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Molecules | AMES Toxicity | Max. Tolerated Dose (Human) |
hERG I Inhibitor | hERG II Inhibitor | Oral Rat Acute Toxicity (LD50) | Oral Rat Chronic Toxicity (LOAEL) | Hepatotoxicity | Skin Sensitization |
T. Pyriformis Toxicity |
Minnow Toxicity |
| M33 | No | 0.091 | No | No | 2.472 | 1.379 | No | No | 1.994 | 1.289 |
| M36 | No | 0.225 | No | Yes | 2.276 | 2.261 | No | No | 0.894 | 0.054 |
| M72 | No | −0.127 | No | Yes | 2.751 | 1.531 | Yes | No | 1.207 | 0.478 |
| M74 | No | −0.142 | No | Yes | 2.776 | 1.556 | Yes | No | 0.898 | 0.748 |
| M76 | No | −0.119 | No | Yes | 2.615 | 1.649 | Yes | No | 1.253 | 0.768 |