TABLE 4.
Evolution of the susceptibility to malaria and the ability of sera to agglutinate a CSA-adherent parasite and an ICAM-1-adherent isolate in 45 primigravidae from Ebolowa monitored during two consecutive pregnancies
| Parameter | Result for:
|
Pb | ||||
|---|---|---|---|---|---|---|
| First pregnancy
|
Six mo after delivery | Second pregnancy
|
||||
| Sixth mo | Delivery | Sixth mo | Delivery | |||
| No. of women | 45 | 23 | 33 | 13 | 5 | |
| Infection (%)a | 46.7 | 65.2 | 6.1 | 7.7 | 0 | 0.005 |
| Agglutination of a CSA-adherent parasite (RP5) | ||||||
| Positive tests (%) | 31.8 | 66.7 | 54.5 | 76.9 | 80 | 0.002 |
| Agglutination index (mean ± SD) | 16.3 ± 4.0 | 23.0 ± 4.3 | 15.5 ± 1.9 | 13.0 ± 3.8 | 9.7 ± 1.6 | |
| Agglutination of an ICAM-1-adherent parasite | ||||||
| Positive tests (%) | 20.5 | 40.9 | 31.0 | 30.8 | 20 | NSc |
| Agglutination index (mean ± SD) | 5.8 ± 2.5 | 5.8 ± 1.9 | 6.1 ± 1.4 | 4.1 ± 0.2 | 7.5 | |
a
Peripheral infection at the 6th month of pregnancy and 6 months after delivery; placental infection at delivery.
b
Sixth month of first pregnancy versus 6th month of second pregnancy (Fisher’s exact test).
c
NS, not significant.