Table 1.
Type of data subject to collection during visits.
| Domain | Measures (Itemized) |
|---|---|
| General information | Patient’s code (individual identification No.); age; ethnicity; main occupation for the last 12 months; menopause; BMI* |
| Breast cancer features | Tumor clinical staging; tumor histotype; tumor clinical classification; IHC* data |
| Presence of risk factors | BC hereditary factor; smoking; physical activity (hour, min); history of stroke; IHD*, CHF* (functional class); Charlson comorbidity index (disease, scores); arterial hypertension; diabetes mellitus (presence/absence) |
| Clinical examination at admission | Heart rate; SBP*; DBP*; 6-min walk test (functional class, meters); selected clinical and biochemical lab tests; ECG* and Holter monitoring (HM every 6 months) |
| Breast cancer treatment | Medications prescribed (dose, regimen) Previous treatment, before admission to chemotherapy division: radiation (dose, regimen), surgical (radical, sectoral) |
| Cardiac protectors prescribed | ACE* inhibitors/ARBs*; beta-blockers; statins; trimetazidine/analogues; others |
| Echocardiographic data and biomarkers | See Figure 1 (including time periods of change onset) |
| Complications of Chemotherapy | |
| CTRCD conditions | Code; type; form; time of emergence |
| Other complications | Hematopoietic system complications; thromboembolic complications; pericarditis; gastrointestinal tract; respiratory system; urinary system; allergic reactions; neurotoxicity; toxic effects on the skin and appendages; toxic hyperthermic reactions; toxic phlebitis |
| Chemotherapy outcomes | Without complications; CT* correction due to CTRCD; CT interruption due to CTRCD; CT correction due to non-CTRCD complications; CT interruption due to non-CTRCD complications |
| Completeness of chemotherapy | (%) |
| Death | (Cause; date) |
| Dropped out of the study | Reason |
*ACE—angiotensin-converting enzyme inhibitors; *ARBs—angiotensin II receptor blockers; *BMI—body mass index; *CHF—chronic heart failure; *CT—chemotherapy; *ECG—electrocardiogram; *IHC—immunohistochemical test; *IHD—ischemic heart disease; *SBP, *DBP—systolic, diastolic blood pressure.