Table 2.
Subgroup analyses for diagnostic values of Superb Microvascular Imaging to differentiate benign and malignant breast lesions.
| Subgroup | Study Sample | Sen [95% CI; I2, %] |
Spe [95% CI; I2, %] |
PLR [95% CI; I2, %] |
NLR [95% CI; I2, %] |
DOR [95% CI;] |
|---|---|---|---|---|---|---|
| Country | ||||||
| China | 17 | 0.79 [0.76, 0.82; 34.61] | 0.86 * [0.81, 0.90; 82.31] | 5.5 * [4.2, 7.3; 80.03] | 0.24 [0.21, 0.28; 17.43] | 23 * [17,31] |
| Korea or Turkey | 6 | 0.80 [0.75, 0.85; 11.41] | 0.77 * [0.67 0.87; 81.65] | 3.6 * [2.2, 6.0; 63.86] | 0.25 [0.18, 0.34;43.41] | 14 * [7,30] |
| Study Design | ||||||
| Retro | 16 | 0.80 [0.77, 0.83; 22.27] | 0.85 [0.80, 0.88; 78.68] | 5.2 [3.9, 6.9; 68.84] | 0.24 [0.20, 0.27; 32.55] | 22 [15,32] |
| Pro | 7 | 0.79 [0.73, 0.84; 45.12] | 0.82 [0.68, 0.90; 90.85] | 4.3 [2.5, 7.3; 79.40] | 0.26 [0.21, 0.32; 0.00] | 17 [10,29] |
| Diagnostic Basis | ||||||
| AC | 8 | 0.82 [0.77, 0.86; 11.98] | 0.82 [0.77, 0.88; 81.02] | 4.5 [3.1, 6.6; 60.62] | 0.22 [0.18, 0.28; 0.00] | 20 [13,31] |
| PV | 2 | 0.81 [0.71, 0.89] | 0.77 * [0.67, 0.85] | 3.8 * [1.5, 9.6] | 0.25 [0.15, 0.39] | 16 * [5,52] |
| MVDP | 7 | 0.76 [0.70, 0.80; 35.69] | 0.91 * [0.88, 0.93; 0.00] | 8.1 * [6.1, 10.8; 0.00] | 0.27 [0.22, 0.33; 33.58] | 30 * [20,46] |
| VI | 6 | 0.81 [0.77, 0.85; 22.24] | 0.77 [0.64, 0.87; 82.47] | 3.6 [2.1, 6.0; 65.20] | 0.24 [0.18, 0.32; 48.02] | 15 [7,30] |
| Overall | 23 | 0.80 [0.77, 0.84; 28.32] | 0.84 [0.79, 0.88; 84.36] | 4.9 [3.8, 6.3; 76.23] | 0.24 [0.22, 0.27; 17.87] | 20 [15,27] |
AC, Alder classification; DOR, diagnostic odds ratio; MVDP, microvascular distribution pattern; NLR, negative likely ratio; PLR, positive likely ratio; PV, penetrating vessel; Sen, sensitivity; Spe, specificity; VI, vascular index; *: p < 0.05.