Table 7.

Regression coefficients and their significances for 3-Met production from the results of the BBD.

Source	Sum of Squares	DF	Mean Square	F Values	p Values	Significance
Model	4.18	9	0.4643	18.54	0.0025	**
A—Time point of L-Met addition	0.2722	1	0.2722	10.87	0.0215	*
B—Glucose concentration	0.6188	1	0.6188	24.71	0.0042	**
C—Yeast extract concentration	0.6757	1	0.6757	26.98	0.0035	**
AB	0.0051	1	0.0051	0.2029	0.6713
AC	0.0007	1	0.0007	0.0293	0.8708
BC	0.0692	1	0.0692	2.76	0.1574
A2	0.8383	1	0.8383	33.47	0.0022	**
B2	0.7690	1	0.7690	30.70	0.0026	**
C2	1.31	1	1.31	52.28	0.0008	***
Residual	0.1252	5	0.0250
Lack of Fit	0.1019	3	0.0340	2.91	0.2658	Not significant
Pure Error	0.0233	2	0.0117
Cor Total	4.30	14
	R2 = 0.9709	R2Adj = 0.9185	CV = 7.42%

Note: “*”, Significant at 5% level (p <0.05); “**”, significant at 1% level (p < 0.01); “***” Significant at 0.11% level (p < 0.001).