Table 2.

Midazolam concentration according to genotype and stratified by age.

Age (years)	Genotype	N (%) 55 (100)	Midazolam at 3 h	p-Value	Midazolam at 24 h	p-Value
			Median (Q25–Q75)		Median (Q25–Q75)
	CYP3A4/rs2740574
≤five	Dominant
	CC+CT	2 (9)	386.61 (191.98–581.24)	0.2	111.49 (0.0–222.9)	0.9
	TT	21 (91)	0.0 (0.0–459)		0.0 (0.0–0.0)
	Recessive
	CC	0	NC	NC	NC	NC
	CT+TT	23 (100)	79.52 (0.00–487.96)		1.0 (0.00–85.14)
>five	Dominant
	CC+CT	5 (16)	23.51 (0.00–96.2)	0.1	0.00 (0.00–79.03)	0.6
	TT	27 (84)	146.83 (0.00–332.5)		0.00 (0.00–133.23)
	Recessive
	CC	0	NC		NC
	CT+TT	32 (100)	119.67 (0.00–332.5)	0.3	0.00(0.00–133.23)	0.5
	CYP3A5/rs776746
≤five	Dominant
	TT+TC	11 (48)	0.0 (0.00–0.00)	0.005 *	0.00 (0.00–0.00)	0.5
	CC	12 (52)	438.17(135.75–580.24)		0.00 (0.00–196.64)
	Recessive
	TT	0	NC	NC	NC	NC
	TC+CC	23 (100)	79.52 (0.00–487.96)		0.00 (0.00–85.14)
>five	Dominant
	TT+TC	16 (50)	27.45 (0.00–206.96)	0.055	0.00 (0.00–89.09)	0.2
	CC	16 (50)	276.04(15.05–370.29)		62.97 (0.00–172.0)
	Recessive
	TT	2 (6)	104.7 (0.00–209.5)	0.6	84.46 (0.00–168.9)	0.8
	TC+CC	30(94)	119.67 (0.00–342.5)		0.00 (0.00–99.1)

* Statistical significance was calculated using the nonparametric Mann–Whitney U test; NC = Not calculable.