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. 2022 Nov 1;39(21-22):1575–1590. doi: 10.1089/neu.2022.0044

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© Marc Joshua Silvosa et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 3. — High-frequency pressure blasts enhances network oscillations in human cerebral organoids. (A) Top, representative spectrograph from a single channel of a 5-sec epoch at 1 h from a control organoid. Bottom, raw signal from the single multi-electrode array channel. (B) Top, representative spectrograph of a single channel at 1hr after exposure to low-frequency pressure wave. Bottom, raw signal that corresponds to the above spectrograph. (C) Normalized fast Fourier transform (FFT) of each group. (D) Quantification of normalized peak power across all pressure wave parameters tested. Error bars presented as standard error of the mean. *p < 0.05, n = 12 organoids per group. All statistics calculated using one-way analysis of variance. Color image is available online.