Figure 1.

Flow Chart. (A) Data acquisition. (B) The set of microRNAs (miRNAs) with major synergistic effect was screened by the synthesis algorithm Optimized Scoring Mechanism for Primary Synergy MicroRNAs (O-PSM). 1. Four-fold cross sampling. 2. Differential expression analysis. 3. Clustering was performed using the pearson correlation coefficient. 4. The significant decision tree models were obtained by t test and decision tree. 5. Screening primary synergy gene sets by single Area Under Curve (AUC) of each miRNA > 0.7. 6. After rating the primary synergy gene sets, keep the highest scoring marker set. (C) Results validation.