Figure 3.

The potential oncogenic functions of Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) in kidney cancer and tumor-suppressive roles in other cancer types. (a) SPOP exerts potential antitumor activity by regulating proliferation, migration, invasion, metastasis, apoptosis, drug resistance, cell senescence and lymphocyte infiltration via modulating various substrates in PrCa. (b) SPOP has tumor-suppressive effects across multiple cancer types, including endometrial, gastric, colorectal, cervical and lung cancers, hepatocellular carcinoma, choriocarcinoma, Ewing sarcoma and diffuse large B-cell lymphoma. It has dual roles in breast cancer that regulate the degradation of its various substrates. (c) SPOP exerts its potential oncogenic activity by enhancing the ubiquitination and degradation of Phosphatase and tensin homolog (PTEN), Dual-Specificity Phosphatase 7 (DUSP7), Gli2 and SETD2 to promote renal carcinogenesis.