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. 2022 Nov 20;13(11):2165. doi: 10.3390/genes13112165

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CBD molecular targets. CBD can target different molecules in the brain, including membrane (CB1, CB2, TRPV1 and GPR55) and nuclear (PPARy) receptors, enzymes and transporters, thereby regulating the neurochemical milieu and transcription in different ways [42]. Lines represent the mechanism of action: red lines = inhibitor/antagonist; dashed red lines = negative allosteric modulation; dark lines = agonist; dashed black lines = partial agonist. D2: dopamine-2 receptor; MOR: mu-opioid receptor; A2: adenosine-2 receptor.