Table 5. Summary of negative stain EM images classified as open vs. closed conformation.
Preparation | WT(% closed) | WT(% open) | E525K(% closed) | E525K(% open) | % E525K closed/% WT closed |
---|---|---|---|---|---|
1 | 16.9 | 83.1 | 56.9 | 43.1 | 3.4 |
2 | 8.5 | 91.5 | 34.8 | 65.2 | 4.1 |
3 | 6.5 | 93.5 | 27.0 | 73.0 | 4.2 |