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Proposed mechanism for integration of the pPNG301 and pPNG302 plasmids into the L. fermentum BR11 chromosome, downstream of the bspA promoter, via single-crossover homologous recombination. The bspA promoter is indicated as P ➞. The DNAs encoding the gp41(556–590) and OmpA(293–346) antigens are shown as gp41 and OmpA, respectively.
